Review Article
Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus
Table 4
Previous GAS human challenge studies. CFU/mL: colony-forming units per millilitre.
| Year | Strain | Dose (CFU/mL) | Number of participants | Number of not vaccinated | Clinical illness in nonvaccine group | Reference |
| 1971 | M1 | 4 × 106 | 50 | 25 | 52% | [94] | 1973 | M1 | 4 × 106 | 44 | 23 | 74% | [95] | 1975 | M3, M12 | 5 × 106 | 84 | 36 | 44% | [96] |
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