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Journal of Immunology Research
Volume 2015 (2015), Article ID 174164, 9 pages
http://dx.doi.org/10.1155/2015/174164
Review Article

Research Progress on Regulatory T Cells in Acute Kidney Injury

1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
2Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China

Received 14 May 2015; Accepted 2 July 2015

Academic Editor: Eyad Elkord

Copyright © 2015 Yamei Wang and Yuhong Tao. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Immune inflammation is crucial in mediating acute kidney injury (AKI). Immune cells of both the innate and adaptive immune systems substantially contribute to overall renal damage in AKI. Regulatory T cells (Tregs) are key regulator of immunological function and have been demonstrated to ameliorate injury in several murine experimental models of renal inflammation. Recent studies have illuminated the renal-protective function of Tregs in AKI. Tregs appear to exert beneficial effects in both the acute injury phase and the recovery phase of AKI. Additionally, Tregs-based immunotherapy may represent a promising approach to ameliorate AKI and promote recovery from AKI. This review will highlight the recent insights into the role of Tregs and their therapeutic potential in AKI.