Review Article

How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines

Table 3

An overview of the currently available Neisseria meningitidis vaccines.

VaccineManufacturerSerogroupsLicensed age groupAdministration scheduleComponents details

AC VaxGlaxoSmithKline, UKA, C2 y+Single dose50 μg each of meningococcal polysaccharides

ACWY VaxGlaxoSmithKline, UKA/C/Y/W-1352 y+; can be given also at 2 mo+, even though less protective against C, Y, and W-135Single dose50 μg each of meningococcal polysaccharides

Bexsero (4CMenB)Novartis Vaccines and DiagnosticsB2 mo–17 yComplex dose schedule depending on age: 3 doses + booster for 2–5 mo; 2 doses + booster at 6–23 mo; 2 doses at 2+ y50 μg of each recombinant NHBA, NadA, fHbp fusion proteins, OMVs from strain NZ98/254 containing the PorA P1.4 (25 µg), adsorbed on 0.5 mg Al3+

HexaMen and HexaMixNational Institute for Public Health and the Environment, Bilthoven, NetherlandsB2, 3, and 4 mo, a booster dose at 12–18 moOMV from two recombinant engineered strains, each of which expressed three different PorA subtypes (P1.5-2, 10; P1.12-1, 13; P1.7-2, 4; P1.19, 15-1; P1.7, 16; and P1.5-1, 2-2)

Menactra (MenACWY-DT)Sanofi PasteurA/C/Y/W-1359 mo–55 ySingle dose4 μg each of meningococcal polysaccharides conjugated to 48 μg of a diphtheria toxoid protein carrier

MenAfriVac (MenA-TT)Serum Institute of IndiaA1–29 ySingle dose10 μg of meningococcal group A polysaccharides conjugated to 10 to 33 μg tetanus toxoid

MenBvacNational Institute for Public Health, Norway, and NovartisB3 doses (interval 5–12 w)OMVs from the strain 44/76 adsorbed on Al3+

MencevaxAGlaxoSmithKline and RIT, BelgiumA2 y+Single dose50 μg of meningococcal group A polysaccharides
No conjugation

MencevaxACGlaxoSmithKlineA, C2 y+Single dose50 μg each of meningococcal group polysaccharides
No conjugation

MencevaxACYGlaxoSmithKlineA, C, Y2 y+Single dose50 μg each of meningococcal group polysaccharides
No conjugation

MencevaxACYWGlaxoSmithKlineA/C/Y/W-1352 y+Single dose50 μg each of meningococcal group polysaccharides
No conjugation

Mengivac A + C (MenPS)Sanofi PasteurA, C50 μg of meningococcal group C polysaccharides

MenHibrix (HibMenCY-TT) GlaxoSmithKlineC, Y6 w–18 mo2, 4, 6, and 12 to 15 moMeningococcal groups C and Y polysaccharides conjugated to tetanus toxoid

Meningitec (MenC-CRM)Wyeth Vaccines, Canada, UK, and AustraliaC2 mo+3 doses at 2–12 mo, 1 dose at 12 mo+ 10 μg of meningococcal group C polysaccharides conjugated to 15 μg CRM197

MeninvactSanofi PasteurC2 mo+2 doses at 2–12 mo, 1 dose at 12 mo+Meningococcal group C polysaccharides conjugated to CRM197

Menitorix (Hib-MenC-TT)GlaxoSmithKlineC6 w–12 moBooster at 1-2 yMeningococcal group C polysaccharides conjugated to tetanus toxoid

Menjugate (MenC-CRM)Novartis Vaccines and DiagnosticsC2 mo+3 doses at 2–12 mo; 1 dose at 12 mo+10 μg of meningococcal group C polysaccharides conjugated to 12.5 to 25 μg CRM197

MenomuneSanofi PasteurA, C2 y+Single dose50 μg each of meningococcal group polysaccharides
No conjugation

MenomuneSanofi PasteurA/C/Y/W-1352 y+Single dose50 μg each of meningococcal group polysaccharides
No conjugation

MenovacFinlay InstituteA/C/Y/W-1352–55 ySingle doseMeningococcal group polysaccharides

Menveo (MenACWY-CRM197)Novartis Vaccines and DiagnosticsA/C/Y/W-1352–55 ySingle dose10 μg of meningococcal group A polysaccharides and 5 μg of meningococcal groups C, Y, and W-135 polysaccharides conjugated to CRM197

MeNZBInstitute for Public Health, New Zealand, Chiron, NovartisBOMVs from strain P1.7b, 4

NeisVac-C (MenC-TT)Baxter BioScienceC2 mo–65 y2 doses at 2–12 mo (with an interval of at least 2 mo), 1 dose at 12 mo+10 μg of meningococcal group C polysaccharides conjugated to tetanus toxoid

NimenrixGlaxoSmithKlineA/C/Y/W-1351 y+Single dose5 μg each of meningococcal group polysaccharides conjugated to 44 μg tetanus toxoid

NmVac4JN-International Medical CorporationA/C/Y/W-1352–55 ySingle dose50 μg each of meningococcal group polysaccharides

TrumenbaPfizerB10–25 y3 doses (0–2–6 mo)120 µg of recombinant fHbp adsorbed on 0.25 mg Al3+

ZamevaxImunoloski Zavod, CroatiaA, CNo conjugation

CRM197: cross-reacting material 197; fHbp: factor H binding protein; mo: month; NadA: Neisseria adhesion A; NHBA: Neisseria heparin binding antigen, also named GNA2132; OMV: outer membrane vesicle; PorA: porin A; w: week; y: year; Al3+: Aluminum.