Impact of Pneumococcal Conjugate Universal Routine Vaccination on Pneumococcal Disease in Italian Children
Table 2
Cases of IPD and pneumococcal pneumonia and matched controls. PCVs effectiveness (95% CIs) in Puglia, 2006–2012.
Vaccination status
IPD cases ()
Matched controls ()
OR (95% CI)
VE (95% CI)
%
%
Fully vaccinated#
8
88.89
26
96.30
0.31 (0.12–0.7)
0.003
69% (30%–88%)
Incompletely vaccinated##
1
11.11
0
0
n.c.
0.31
Not vaccinated
0
0
1
3.70
Ref.
Ref.
Vaccination status
Pneumococcal pneumonia cases
Matched controls
OR (95% CI)
VE (95% CI)
()
()
%
%
Fully vaccinated#
19
63.33
81
90.00
0.23 (0.13–0.39)
<0.001
77% (61%–87%)
Incompletely vaccinated##
11
36.67
7
7.78
1.57 (0.56–4.78)
>0.05
Not vaccinated
0
0
2
2.22
Ref.
Ref.
Vaccination status
Total cases ()
Matched controls ()
OR (95% CI)
VE (95% CI)
%
%
Fully vaccinated#
27
69.23
107
91.46
0.25 (0.16–0.39)
<0.001
75% (61%–84%)
Incompletely vaccinated##
12
30.77
7
5.98
1.71 (0.62–5.13)
>0.05
Not vaccinated
0
0
3
2.56
Ref.
Ref.
Fully vaccinated cases: children vaccinated with ≥3 doses of PCV7/PCV13 at least one month before the date of hospitalization; fully vaccinated control: presumed healthy children vaccinated with ≥3 doses. ##Incompletely vaccinated cases: children vaccinated with <3 doses of PCV7/PCV13 at least one month before the date of hospitalization; incompletely vaccinated control: presumed healthy children vaccinated with <3 doses. Exact McNemar significance probability. n.c.: not calculable. Power of estimation: 84.6%.
