Impact of Pneumococcal Conjugate Universal Routine Vaccination on Pneumococcal Disease in Italian Children

Table 3

Hospitalization rates (per 100,000) and HRRs (95% CIs) for IPD, Streptococcus pneumoniae pneumonia, all-cause pneumonia, and AOM in the pre- and postvaccination period in Italy and in the first eight regions that introduced PCVs in 2006.

Italy	2001–2005		2006–2011		HRR (95% CI)
		Rate per 100,000		Rate per 100,000
IPD	163	6.14	112	4.04	0.66	(0.52–0.84)
Pneumococcal pneumonia	488	18.37	715	25.74	1.4	(1.25–1.57)
All-cause pneumonia	21,406	805.76	22,354	804.90	0.99	(0.98–1.02)
AOM	2,658	100.07	1.703	61.33	0.61	(0.58–0.65)
Eight regions which introduced PCV in 2006	2001–2005		2006–2011		HRR (95% CI)
		Rate per 100,000		Rate per 100,000
IPD	53	5.49	28	2.90	0.51	(0.32–0.81)
Pneumococcal pneumonia	127	13.23	205	21.40	1.57	(1.26–1.96)
All-cause pneumonia	7,287	760.09	7,430	775.03	0.99	(0.95–1.02)
AOM	870	90.79	565	58.94	0.63	(0.57–0.70)