Journal of Immunology Research / 2015 / Article / Tab 1

Research Article

Impact of Inflammatory Cytokine Gene Polymorphisms on Developing Acute Graft-versus-Host Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Table 1

Association between clinical variable and aGvHD.

Tot. = 117%GVHD I–IVGVHD II–IVGVHD III-IV
Tot. = 73%Tot. = 48 %P Tot. = 13%

Sex
 Recipient
  M8270.0%4858.5%0.21 3239.0%0.54 78.5%0.20
  F3530.0%2571.4%1645.7%617.1%
 Donor
  M7362.3%4764.3%1.00 3142.4%0.70 912.3%0.76
  F4437.7%2659.0%1738.6%49.0%
Underlying disease
 Leukemia and lymphoma8169.2%5061.7%0.33 3644.4%0.47 89.8%0.28
 Solid tumors1714.5%1376.4%529.4%15.8%
 Nononcologic disease1916.3%1052.6%736.8%421.0%
Transplantation type
 Matched, related4336.8%2558.1%0.74 1739.5%0.91 49.3%0.37
 Matched, unrelated4763.8%3063.8%2042.5%48.5%
 Mismatch, unrelated2723.0%1866.6%1244.4%518.5%
Conditioning regimen
 TBI-based 2218.9%1672.7%0.33 1359.0%0.10 313.6%0.70
 BU-based9581.1%5760.0%3536.8%1010.5%
Stem cells sources
 Bone marrow9278.6%6065.2%0.025 4144.5%0.17 77.6%0.003*
 PBSC2521.4%1352.0%728.0%624.0%
GVHD prophylaxis
 CSA only3328.2%1957.5%0.52 1133.3%0.30 26.0%0.34
 CSA + other8471.8%5464.2%3744.0%1113.0%
Number of HSCT
 110186.3%6261.3%0.78 4039.6%0.58 1110.8%1.00
 >11623.7%1168.5%850.0%212.5%

M: male; F: female; yrs: years; TBI: total body irradiation; BU: busulfan; GVHD: graft versus host disease; CSA: cyclosporine A; PBSC: peripheral blood stem cells; * < 0.05.

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