Journal of Immunology Research / 2015 / Article / Tab 2

Research Article

Impact of Inflammatory Cytokine Gene Polymorphisms on Developing Acute Graft-versus-Host Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Table 2

Univariate and multivariate analysis of the variables significantly associated with severe GvHD.

aGvHD with outcome/ with variant with outcome/ without variantUnivariate Multivariate
ODDS ratio CI 95%ODDS ratioCI 95%

IL10-1082GG
DNR
II–IV12/16 (75.0%)33/85 (38.8%)3.771.33–12.00.0124.501.45–16.580.008
III-IV4/16 (25.0%)7/85 (8.2%)4.211.17–14.650.0295.150.95–30.150.057

FAS-670CC + CT
DNR
II–IV38/74 (52.3%)7/27 (25.9%)2.811.12–7.650.0272.901.11–8.350.029
III-IV11/74 (14.9%)0/27 (0%)9.811.20–12740.029ns

TLR4-3612TT
DNR
III-IV11/51 (21.6%)2/56 (3.4%)6.821.88–36.470.00212.862.47–138.80.001

IL18-607TT + TG
PT
II–IV39/77 (50.6%)7/30 (23.3%)3.081.25–8.310.014ns

SSCIII-IV3.831.25–8.510.0036.201.40–32.310.016

DNR: donor; PT: patient; SSC: source of stem cells; ns: not significant.

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