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Journal of Immunology Research
Volume 2015 (2015), Article ID 257879, 7 pages
Review Article

Vitamin D and Atopic Dermatitis in Childhood

1Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 11 Piazza Giulio Cesare, 70124 Bari, Italy
2Section of Dermatology, Vito Fazzi Hospital, Piazza Filippo Muratore, 73100 Lecce, Italy

Received 24 September 2014; Accepted 9 January 2015

Academic Editor: Marco Antonio Velasco-Velázquez

Copyright © 2015 Michelangelo Vestita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Vitamin D features immunomodulatory effects on both the innate and adaptive immune systems, which may explain the growing evidence connecting vitamin D to allergic diseases. A wealth of studies describing a beneficial effect of vitamin D on atopic dermatitis (AD) prevalence and severity are known. However, observations linking high vitamin D levels to an increased risk of developing AD have also been published, effectively creating a controversy. In this paper, we review the existing literature on the association between AD and vitamin D levels, focusing on childhood. As of today, the role of vitamin D in AD is far from clear; additional studies are particularly needed in order to confirm the promising therapeutic role of vitamin D supplementation in childhood AD.