GDF15(MIC1) H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis
Table 3
Characteristics associated with CVD in RA patients.
Variable
CVD
Non-CVD
value
130/187 (69.5)
57/187 (30.5)
Median (IQR)
Median (IQR)
Duration of the disease (y)
14.6 (9.038)
9 (5.565)
<0.001
EAM (m)
17.115 (37.6)
4.962 (9.559)
0.028
Mean arterial pressure
99.709 (12.992)
95.491 (11.605)
0.0361
Variable
ECV
Non-ECV
OR (95% CI)
(%)
(%)
Clinical cluster 1&
112/130 (86.1)
32/57 (56.1)
33.93 (8.6–259.7)
<0.001
Time cluster 1#
62/130 (47.6)
24/57 (42.1)
1.99 (1.07–4.16)
0.0274
Current smoking
29/130 (22.3)
4/57 (7.4)
2.54 (1.01–8.45)
0.0312
GDF15 rs1058587 CC
89/130 (68.4)
36/57 (63.1)
—
NS
GDF15 rs1058587 CG
35/130 (26.9)
21/57 (36.8)
—
NS
GDF15 rs1058587 GG
6/130 (4.6)
0/57 (0)
—
NS
Allele C
213/260 (81.9)
93/114 (81.5)
—
NS
Allele G
41/260 (15.7)
21/114 (18.4)
—
NS
CVD: cardiovascular disease; EAMs: extra-articular manifestations; GDF15: growth differentiation factor 15; IQR: interquartile range; y: years; m: months; NS: not significant; RA: rheumatoid arthritis. &Clinical cluster 1 corresponds to patients with the highest frequency of comorbidity, with moderate frequency of EAM, and without Sjögren’s syndrome. #Time cluster 1 corresponds to patients with later age at onset and shorter duration of the disease.
