The Complex Role of STAT3 in Viral Infections

Figure 2

STAT3 signal transduction pathway. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated kinases and then forms homo- or heterodimers. STAT3 dimers then translocate to the nucleus where they act as a transcription activator and mediate the expression of a variety of genes. STAT3 activates the transcription of suppressors of cytokine signalling 3 (SOCS3) which act as classical feedback inhibitor of STAT3 activation.