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Journal of Immunology Research
Volume 2015, Article ID 284215, 13 pages
Research Article

Mesenchymal Stem Cells from Patients with Rheumatoid Arthritis Display Impaired Function in Inhibiting Th17 Cells

1Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China
2Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210000, China

Received 24 December 2014; Revised 3 March 2015; Accepted 4 March 2015

Academic Editor: Ethan M. Shevach

Copyright © 2015 Yue Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Bone marrow derived MSCs were positive for CD44, CD73, CD166, and CD105 and negative for CD14, CD45, CD34, and CD31 as shown by flow cytometry analysis (Figure S1). The ability of RA MSCs to differentiate into osteogenic or adipogenic lineages was indistinguishable from that of controls as shown by cytochemical staining and expression of Runx2 and PPAR?? (Figure S2). Cytokines for each dot in the protein array (in Result 3.4.) are shown in Figure S3.

  1. Supplementary Material