Development of Nonaggregating Poly-A Tailed Immunostimulatory A/D Type CpG Oligodeoxynucleotides Applicable for Clinical Use

Figure 13

Cytokine profiles of D-type CpG ODNs in human PBMCs. PBMCs from three Japanese adult volunteers were stimulated with D35, D35-dAs40, D35-SPG, or medium. Each ODN was serially diluted (0.74, 2.2, 6.6, or 20 μg/mL). After 24 hours, the cytokine concentrations in the supernatants were determined with Milliplex cytokine assay kit.

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