Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1/STAT5 Signalling Response in Helper T Lymphocytes

Figure 2

Treg lymphocyte subset difference among populations. (a) The percentage of aTreg lymphocytes was higher in adults compared to children as well as adolescents. (b) The percentage of rTreg lymphocytes decreased with age. There was a significant difference between all three subject groups. (c) The percentage of total Treg lymphocytes dropped with age as well, but there was no significant difference between the groups of adolescents and adults. (d) The percentage of Teff lymphocytes escalated significantly with age. (e) The ratio between Teff and Treg lymphocytes increased with age with a significant difference between children and adolescents as well as between children and adults. (f) The percentage of CD25−FoxP3+ Th lymphocytes dropped significantly from childhood to adolescence and stayed low in adults. Each symbol in graphs (a) to (d) represents a single sample. The black lines in graphs (a) to (d) indicate the mean value with standard deviations. ; ; ; . (g) Gating strategies and staining patterns for identification of subpopulations aTreg, rTreg, FoxP3+nonTreg, Teff, and CD25−FoxP3+.

(a)

(b)

(c)

(d)

(e)

(f)

(g)