Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1/STAT5 Signalling Response in Helper T Lymphocytes
Table 2
Studied cell subsets in all three age groups of healthy subjects analysed by flow cytometry (; ; ; ).
Children
Adolescents
Adults
Mean ± SD
Mean ± SD
Mean ± SD
Mean age
20
4.17 ± 3.22
20
17.24 ± 1.93
20
51.17 ± 6.32
NK (% of ly)
20
11.13 ± 4.66
20
16.25 ± 8.12
20
16.35 ± 5.79
B ly (% of ly)
20
20.73 ± 6.84
20
10.85 ± 3.77
20
9.44 ± 4.60
T ly (% of ly)
20
59.97 ± 7.39
20
68.19 ± 8.61
20
69.28 ± 7.96
Th (% of T ly)
20
54.40 ± 8.30
20
58.22 ± 7.06
20
62.86 ± 10.92
Tc (% of T ly)
20
35.02 ± 6.47
20
33.41 ± 6.71
20
31.70 ± 10.38
Th/Tc
20
1.64 ± 0.54
20
1.84 ± 0.54
20
2.30 ± 1.11
DNT (% of T ly)
20
10.08 ± 4.57
20
7.80 ± 2.57
20
4.39 ± 3.11
HLA-DR (% of T ly)
19
13.90 ± 8.02
20
15.66 ± 8.96
20
18.41 ± 7.67
Th1 (% of Th ly)
20
10.57 ± 3.00
20
15.79 ± 4.28
20
19.20 ± 5.82
Th2 (% of Th ly)
20
3.43 ± 1.86
20
3.50 ± 1.26
20
5.62 ± 2.99
Th1/Th2
20
3.82 ± 1.81
20
5.16 ± 2.58
20
4.06 ± 1.73
Th1Th17 (% of Th ly)
20
3.51 ± 2.46
20
9.12 ± 3.70
20
11.47 ± 5.93
Th17CD161+ (% of Th ly)
20
1.20 ± 0.65
20
1.23 ± 0.75
20
2.01 ± 1.08
Th17CD161− (% of Th ly)
20
1.83 ± 1.07
20
2.74 ± 1.40
20
3.58 ± 1.38
Th17 total (% of Th ly)
20
3.03 ± 1.58
20
3.96 ± 1.92
20
5.59 ± 2.27
aTreg (% of Th ly)
20
1.41 ± 0.72
20
1.99 ± 0.72
20
3.00 ± 1.10
rTreg (% of Th ly)
20
5.28 ± 3.17
20
1.68 ± 0.93
20
0.85 ± 0.55
FoxP3+non-Treg (% of Th ly)
20
2.95 ± 1.12
20
3.04 ± 1.12
20
3.23 ± 0.93
Treg total (% of Th ly)
20
6.69 ± 3.41
20
3.67 ± 1.11
20
3.85 ± 1.24
Teff (% of Th ly)
18
26.69 ± 9.80
19
41.30 ± 11.47
20
58.13 ± 16.03
Teff/Treg
18
4.25 ± 2.34
19
11.66 ± 4.09
20
16.66 ± 7.80
CD25−FoxP3+ (% of Th ly)
20
5.16 ± 3.74
20
1.03 ± 0.67
20
1.27 ± 1.18
STAT5 (ΔMFI)
12
21.8 ± 29.7
12
16.10 ± 10.00
17
27.6 ± 36.9
pSTAT5 (ΔMFI)
20
240.4 ± 214.8
20
174.9 ± 107.5
20
228.4 ± 97.4
STAT1 (ΔMFI)
20
422.6 ± 372.5
20
186.7 ± 202.4
20
200.0 ± 62.3
pSTAT1 (ΔMFI)
7
13.4 ± 17.3
7
5.9 ± 5.3
14
32.4 ± 47.8
WB (×109 mL−1)
20
7.56 ± 3.14
20
6.65 ± 1.50
20
6.90 ± 1.34
ly (×109 mL−1)
20
2.79 ± 1.94
20
1.57 ± 0.48
20
1.80 ± 0.53
NK (×109 mL−1)
20
0.33 ± 0.32
20
0.26 ± 0.18
20
0.30 ± 0.16
B ly (×109 mL−1)
20
0.60 ± 0.47
20
0.17 ± 0.07
20
0.17 ± 0.10
T ly (×109 mL−1)
20
1.63 ± 1.11
20
1.07 ± 0.34
20
1.25 ± 0.38
A, B and C in the table are referring to our three different age groups (as it is indicated in the first row of the table A = children, B = adolescents, C = adults). Abbreviations AB, AC an BC are therefore used to highlight statistically significant differences between compared groups (AB = comparing children to adolescents, AC = comparing children to adults, BC = comparing adolescents to adults).
