Immunomodulatory Effects Mediated by Serotonin

Table 2

The effect of 5-HT on MDDC cytokine production.

Cytokine secretion	5-HT receptors involved	References
↑ IL-6	5HT3, 5HT4 and 5HT7	Müller et al., 2009 [43]
↓ IL-12p70	5HT4 and 5HT7	Müller et al., 2009 [43]
↑ IL-10	5HT4 and 5HT7	Müller et al., 2009 [43]
↑ IL-8, IL-1; ↓ IL-12, TNF-	5HT3, 5HT4 (Gαs-coupled), and 5HTR7 (Gαs-coupled)	Idzko et al., 2004 [2]