Immunomodulatory Effects Mediated by Serotonin

Table 3

Pathology-associated serotonergic protein expression in immune cells.

Patology/condition	5-HT, SERT and 5HTR variation	Reference
Major depression disorder; Human	↓ SERT in platelets; ↓ 5-HT serum levels; ↓ SERT in lymphocytes	Mössner et al., 2007 [63]; Fazzino et al., 2008 [64]; Lima and Urbina, 2002 [52]; Peña et al., 2005 [65]
Fibromyalgia; Human	↓ 5-HT serum levels; ↓ SERT platelets	Bazzichi et al., 2006 [66]
Schizophrenia; Human	↑ 5HT2A (polymorphism T102C) in lymphocytes; ↑ 5HT3A (gene) in PMBC; ↓ SERT (re-uptake) in lymphocytes	Williams et al., 1997 [67]; Abdolmaleky et al., 2004 [68]; Shariati et al., 2009 [69]; Marazziti et al., 2006 [70]
Asthma; Human	↑ 5-HT plasma levels	Lechin et al., 1998 [71]
Alzheimer disease; Human	↑ 5HT2C in NK cells; ↓ 5-HT serum levels	Martins et al., 2012 [72]
Psoriasis; Human	↑ SERT of skin biopsies, dendritic cells	Thorslund et al., 2013 [59]
Alcohol exposition 0.1% 24 h; Culture, dendritic cells	↑ SERT in dendritic cells; ↓ 5-HT extracellular levels	Babu et al., 2009 [73]
Arthritis; Cell culture	↑ 5HT2A mRNA in macrophage-like synovial cells; ↑ 5HT3 mRNA in macrophage-like synovial cells	Seidel et al., 2008 [74]
Mitogen activation with concanavalin; Rat lymphocyte	↑ 5HT7 mRNA	Urbina et al., 2014 [75]