Dendritic Cell Activity Driven by Recombinant Mycobacterium bovis BCG Producing Human IL-18, in Healthy BCG Vaccinated Adults

Figure 8

Secretion of  IFN-γ by human naive and memory T cells following 24 h and 96 h coculture with BCG- (1 : 1), rBCGIL-18- (1 : 1) pulsed autologous MoDCs (ratio MoDCs/T cells, 1 : 10) in the presence (black bars) of neutralizing human anti-IL-18 antibody or not (grey bars). The cytokine level in the cocultures was measured by ELISA. One representative experiment out of three independent ones is shown.