Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis

Table 1

-score based functional prediction of SDEG.

Category	Functions annotation	value	-score	Number of molecules
Downregulated
Inflammatory Response	Activation of leukocytes		−4	103
	Activation of myeloid cells		−4	39
	Activation of phagocytes		−3.7	45
	Activation of antigen presenting cells		−3.3	38
	Inflammatory response		−3.1	107
	Chemotaxis of granulocytes		−3.1	31
	Activation of mononuclear leukocytes		−3	77
	Chemotaxis of neutrophils		−3	27
	Chemotaxis of myeloid cells		−2.9	45
	Activation of macrophages		−2.9	25
	Activation of lymphocytes		−2.8	75
	Phagocytosis		−2.5	45
	Chemotaxis of leukocytes		−2.2	60
	Acute phase reaction		−2.2	7
Cellular movement	Cell movement of leukocytes		−2.7	122
	Lymphocyte migration		−2.7	55
Cell death and survival	Cell death		−2.6	400
Upregulated
Cell morphology	Morphology of mononuclear leukocytes		2.9	45
	Morphology of lymphocytes		2.9	42
	Morphology of leukocytes		2.8	63
	Morphology of blood cells		2.8	68
	Morphology of T lymphocytes		2.2	26
	Morphology of B lymphocytes		2.1	17
Lipid metabolism	Synthesis of phosphatidylcholine		2.2	9
	Metabolism of phosphatidylcholine		2.2	10
Lymphoid tissue structure and development	Morphology of lymph follicle		3.4	28
	Morphology of germinal center		3.2	21
	Development of lymphatic system component		2.3	61
	Development of lymph node		2.9	23
	Lack of germinal center		3.2	11
Molecular transport	Transport of molecule		2.8	176