The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling

Figure 4

Aggregates could contribute to ADA production by increasing danger signal to maturate dendritic cells. ((a)–(f)) Simulated ADA production is shown at various levels of danger signal (DS) which is modeled as the amount of LPS in ng. Remaining parameter values are the same as in the original simulation for nonaggregated adalimumab [47, 48]. DS = 350 ng LPS shows the original simulation for nonaggregated adalimumab [47, 48]. ADA production is shown as the sum of the 17 subgroups. Dose = 40 mg administered biweekly.

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