Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice

Figure 4

Mice expressing mutations in Fas and FasL display significantly greater mortality than wild-type BALB/c mice. A latent infection of BALB/c wild-type ( mice), BALB-lpr ( mice), and BALB-gld ( mice) mice was established as described and mice were observed for mortality for 10 weeks. Data displayed were compiled from two independent studies. Mortality for both BALB-lpr and BALB-gld was significantly greater than that for BALB/c wild-type mice ().