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Journal of Immunology Research
Volume 2015 (2015), Article ID 450391, 9 pages
http://dx.doi.org/10.1155/2015/450391
Research Article

Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies

1Department of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, France
2Department of Neurology, CHU Poitiers, University of Poitiers, 2 Rue de la Milétrie, 86021 Poitiers, France
3Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, 69000 Lyon, France

Received 4 November 2014; Accepted 7 April 2015

Academic Editor: Douglas C. Hooper

Copyright © 2015 Laurent Magy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. J. Kelly Jr., R. A. Kyle, P. C. O'Brien, and P. J. Dyck, “Prevalence of monoclonal protein in peripheral neuropathy,” Neurology, vol. 31, no. 11, pp. 1480–1483, 1981. View at Publisher · View at Google Scholar · View at Scopus
  2. P. E. Braun, D. E. Frail, and N. Latov, “Myelin-associated glycoprotein is the antigen for a monoclonal IgM in polyneuropathy,” Journal of Neurochemistry, vol. 39, no. 5, pp. 1261–1265, 1982. View at Publisher · View at Google Scholar · View at Scopus
  3. I. S. Smith, S. N. Kahn, B. W. Lacey et al., “Chronic demyelinating neuropathy associated with benign IgM paraproteinaemia,” Brain, vol. 106, no. 1, pp. 169–195, 1983. View at Publisher · View at Google Scholar · View at Scopus
  4. N. C. Notermans, J. H. J. Wokke, H. M. Lokhorst, H. Franssen, Y. van der Graaf, and F. G. I. Jennekens, “Polyneuropathy associated with monoclonal gammopathy of undetermined significance. A prospective study of the prognostic value of clinical and laboratory abnormalities,” Brain, vol. 117, no. 6, pp. 1385–1393, 1994. View at Publisher · View at Google Scholar · View at Scopus
  5. I. S. Smith, “The natural history of chronic demyelinating neuropathy associated with benign IgM paraproteinaemia: a clinical and neurophysiological study,” Brain, vol. 117, no. 5, pp. 949–957, 1994. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Chassande, J.-M. Léger, A. B. Younes-Chennoufi et al., “Peripheral neuropathy associated with IgM monoclonal gammopathy: correlations between M-protein antibody activity and clinical/electrophysiological features in 40 cases,” Muscle and Nerve, vol. 21, no. 1, pp. 55–62, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Vital, C. Vital, J. Julien, A. Baquey, and A. J. Steck, “Polyneuropathy associated with IgM monoclonal gammopathy. Immunological and pathological study in 31 patients,” Acta Neuropathologica, vol. 79, no. 2, pp. 160–167, 1989. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Maisonobe, B. Chassande, M. Vérin, M. Jouni, J.-M. Léger, and P. Bouche, “Chronic dysimmune demyelinating polyneuropathy: a clinical and electrophysiological study of 93 patients,” Journal of Neurology Neurosurgery and Psychiatry, vol. 61, no. 1, pp. 36–42, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. J.-M. Vallat, F. Tabaraud, L. Magy et al., “Diagnostic value of nerve biopsy for atypical chronic inflammatory demyelinating polyneuropathy: evaluation of eight cases,” Muscle & Nerve, vol. 27, no. 4, pp. 478–485, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Cocito, G. Isoardo, P. Ciaramitaro et al., “Terminal latency index in polyneuropathy with IgM paraproteinemia and anti-MAG antibody,” Muscle & Nerve, vol. 24, no. 10, pp. 1278–1282, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. Joint Task Force of the EFNS and the PNS, “European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of paraproteinemic demyelinating neuropathies. Report of a Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society—first revision,” Journal of the Peripheral Nervous System, vol. 15, no. 3, pp. 185–195, 2010. View at Google Scholar
  12. Joint Task Force of the EFNS and the PNS, “European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society—first revision,” Journal of the Peripheral Nervous System, vol. 15, no. 1, pp. 1–9, 2010. View at Google Scholar
  13. M. L. Kuijf, M. Eurelings, A. P. Tio-Gillen et al., “Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy,” Neurology, vol. 73, no. 9, pp. 688–695, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. J. M. Vallat, M. O. Jauberteau, D. Bordessoule, C. Yardin, P. M. Preux, and P. Couratier, “Link between peripheral neuropathy and monoclonal dysglobulinemia: a study of 66 cases,” Journal of the Neurological Sciences, vol. 137, no. 2, pp. 124–130, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. M. O. Jauberteau, B. Younes-Chennoufi, M. Rigaud, and N. Baumann, “IGM gammopathy and polyneuropathy react with an antigenic glycolipid present in human central nervous system,” Neuroscience Letters, vol. 97, no. 1-2, pp. 181–184, 1989. View at Publisher · View at Google Scholar · View at Scopus
  16. J. S. Katz, D. S. Saperstein, G. Gronseth, A. A. Amato, and R. J. Barohn, “Distal acquired demyelinating symmetric neuropathy,” Neurology, vol. 54, no. 3, pp. 615–620, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Bouhassira, N. Attal, H. Alchaar et al., “Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4),” Pain, vol. 114, no. 1-2, pp. 29–36, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Nobile-Orazio, N. Meucci, L. Baldini, A. Di Troia, and G. Scarlato, “Long-term prognosis of neuropathy associated with anti-MAG IgM M-proteins and its relationship to immune therapies,” Brain, vol. 123, no. 4, pp. 710–717, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Ellie, A. Vital, A. Steck, J.-M. Boiron, C. Vital, and J. Julien, “Neuropathy associated with ‘benign’ anti-myelin-associated glycoprotein IgM gammopathy: clinical, immunological, neurophysiological pathological findings and response to treatment in 33 cases,” Journal of Neurology, vol. 243, no. 1, pp. 34–43, 1996. View at Google Scholar · View at Scopus
  20. S. Attarian, J. P. Azulay, J. Boucraut, N. Escande, and J. Pouget, “Terminal latency index and modified F ratio in distinction of chronic demyelinating neuropathies,” Clinical Neurophysiology, vol. 112, no. 3, pp. 457–463, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. D. A. Kaku, J. D. England, and A. J. Sumner, “Distal accentuation of conduction slowing in polyneuropathy associated with antibodies to myelin-associated glycoprotein and sulphated glucuronyl paragloboside,” Brain, vol. 117, no. 5, pp. 941–947, 1994. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Vital, A. Lagueny, J. Julien et al., “Chronic inflammatory demyelinating polyneuropathy associated with dysglobulinemia: a peripheral nerve biopsy study in 18 cases,” Acta Neuropathologica, vol. 100, no. 1, pp. 63–68, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. R. H. Quarles, “Myelin-associated glycoprotein in demyelinating disorders,” Critical Reviews in Neurobiology, vol. 5, no. 1, pp. 1–28, 1989. View at Google Scholar · View at Scopus
  24. F. Fluri, F. Ferracin, B. Erne, and A. J. Steck, “Microheterogeneity of anti-myelin-associated glycoprotein antibodies,” Journal of the Neurological Sciences, vol. 207, no. 1-2, pp. 43–49, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. J. M. Gabriel, B. Erne, L. Bernasconi et al., “Confocal microscopic localization of anti-myelin-associated glycoprotein autoantibodies in a patient with peripheral neuropathy initially lacking a detectable IgM gammopathy,” Acta Neuropathologica, vol. 95, no. 5, pp. 540–546, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Caudie, F. Bouhour, P. Petiot et al., “Contribution des autoanticorps IgM anti-SGPG par Elisa Bülhmann au diagnostic de 147 neuropathies périphériques démyélinisantes associées à une IgM monoclonale,” Annales de Biologie Clinique (Paris), vol. 65, no. 4, pp. 369–375, 2007. View at Google Scholar
  27. M. Luigetti, A. Conte, N. Montano et al., “Clinical and pathological heterogeneity in a series of 31 patients with IgM-related neuropathy,” Journal of the Neurological Sciences, vol. 319, no. 1-2, pp. 75–80, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Magy and J.-M. Vallat, “Evidence-based treatment of chronic immune-mediated neuropathies,” Expert Opinion on Pharmacotherapy, vol. 10, no. 11, pp. 1741–1754, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Comi, L. Roveri, A. Swan et al., “A randomised controlled trial of intravenous immunoglobulin in IgM paraprotein associated demyelinating neuropathy,” Journal of Neurology, vol. 249, no. 10, pp. 1370–1377, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Kawagashira, N. Kondo, N. Atsuta et al., “IgM MGUS anti-MAG neuropathy with predominant muscle weakness and extensive muscle atrophy,” Muscle and Nerve, vol. 42, no. 3, pp. 433–435, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. G. Blume, A. Pestronk, and L. T. Goodnough, “Anti-MAG antibody-associated polyneuropathies: improvement following immunotherapy with monthly plasma exchange and IV cyclophosphamide,” Neurology, vol. 45, no. 8, pp. 1577–1580, 1995. View at Publisher · View at Google Scholar · View at Scopus
  32. E. Oksenhendler, S. Chevret, J. Leger et al., “lasma exchange and chlorambucil in polyneuropathy associated with monoclonal IgM gammopathy. IgM-associated Polyneuropathy Study Group,” Journal of Neurology Neurosurgery and Psychiatry, vol. 59, no. 3, pp. 243–247, 1995. View at Publisher · View at Google Scholar · View at Scopus
  33. M. C. Dalakas, G. Rakocevic, M. Salajegheh et al., “Placebo-controlled trial of rituximab in IgM anti-myelin-associated glycoprotein antibody demyelinating neuropathy,” Annals of Neurology, vol. 65, no. 3, pp. 286–293, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. J.-M. Léger, K. Viala, G. Nicolas et al., “Placebo-controlled trial of rituximab in IgM anti-myelin-associated glycoprotein neuropathy,” Neurology, vol. 80, no. 24, pp. 2217–2225, 2013. View at Publisher · View at Google Scholar · View at Scopus