Review Article

Toll-Like Receptor Mediated Modulation of T Cell Response by Commensal Intestinal Microbiota as a Trigger for Autoimmune Arthritis

Figure 2

Toll-like receptor (TLR) activation on antigen presenting cells (APCs) enhances the antigenic signal to T cells. TLR activation induces the upregulation of MHC II (1), costimulatory molecules such as CD80, CD86, and CD40 (2), and release of cytokines (3).