Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination
Table 2
Twelve pentapeptides unique to PV1, Mahoney strain, and absent in the human proteome are distributed among twenty PV-derived epitopes recognized by human sera and/or T cells.
IEDB IDa
Epitope sequenceb,c
PV antigen
PV strain
Immune context
30661
kevpaltavetgat
VP1
PV3 Sabin
B
31814
klefftysRFDMEltfvvtan
VP1
PV1 Mahoney
T
46859
paltavetgatnpl
VP1
PV1 Mahoney
B-T
48785
ppgapvpeKWDDYTWQTssnp
VP1
PV1 Mahoney
T
55952
rsrsessiesf
VP1
PV1 Mahoney
B
58511
siFYTYGtaparisvpyvgi
VP1
PV1 Mahoney
T
59797
snAYSHFYDgfskvplkdqs
VP1
PV1 Mahoney
T
66978
tvdnsasttnkdklfavwk
Polyprotein
PV1 Mahoney
T
71769
vvndhnptkvtsKIRVYlkp
Polyprotein
PV1 Mahoney
T
79155
altlslpkqqdslpdtka
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79160
atnplapsdtvqtrhvvq
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79186
dneqpttraqklfam
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79269
kevpaltavetgatnpla
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79272
khvrVWCPRppravpyyg
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79318
nghalnqvyqimyippga
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79350
qklfamwritykdtv
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79354
qpttraqklfamwri
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79433
traqklfamwrityk
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79434
traqklfamwritykdtv
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79435
trhvvqrrsrsestiesf
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79436
tskvriymkpkhvrvw
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79443
vaiievdneqpttraqkl
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79461
vrvvndhnptkvtskvri
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
79480
yippgaptpksWDDYTwq
Polyprotein
PV3 (P3/LEON/37 and P3/LEON 12A (1)B)
T
80446
argacvtimtvdnpa
VP1
PV1 Mahoney
B
81394
easgpthskeipalt
VP1
PV1 Mahoney
B
82831
gpthskeipaltave
VP1
PV1 Mahoney
B
83234
hskeipaltavetga
VP1
PV1 Mahoney
B
88446
sdtvqtrhvvqhrsr
VP1
PV1 Mahoney
B
88495
sessiesffargacv
VP1
PV1 Mahoney
B
99863
aaparisvpyvgla
Polyprotein
PV3 Sabin
B
99886
ahskevpaltavet
Polyprotein
PV3 Sabin
B
99901
arisvpyvglanay
Polyprotein
PV3 Sabin
B
99910
AYSHFYDgfakvpl
Polyprotein
PV3 Sabin
B
99933
dfgvlavrvvndhn
Polyprotein
PV3 Sabin
B
99963
dtvqlrrkleffty
Polyprotein
PV3 Sabin
B
100029
famwritykdtvql
Polyprotein
PV3 Sabin
B
100101
hfydgfakvplktd
Polyprotein
PV3 Sabin
B
100117
hnptkvtskvriym
Polyprotein
PV3 Sabin
B
100138
iFYTYGaaparisv
Polyprotein
PV3 Sabin
B
100244
lanAYSHFYDgfak
Polyprotein
PV3 Sabin
B
100349
npsiFYTYGaapar
Polyprotein
PV3 Sabin
B
100382
pkhvrVWCPRppra
Polyprotein
PV3 Sabin
B
100391
psdtvqtrhvvqrr
Polyprotein
PV3 Sabin
B
100425
qklfamwritykdt
Polyprotein
PV3 Sabin
B
100430
qlrrklefftysrf
Polyprotein
PV3 Sabin
B
100439
qpttraqklfamwr
Polyprotein
PV3 Sabin
B
100482
rppravpyygpgvd
Polyprotein
PV3 Sabin
B
100492
samtvddfgvlavr
Polyprotein
PV3 Sabin
B
100504
sevaqgaltlslpk
Polyprotein
PV3 Sabin
B
100536
svpyvglanAYSHF
Polyprotein
PV3 Sabin
B
100559
tkvtskvriymkpk
Polyprotein
PV3 Sabin
B
100573
traqklfamwrity
Polyprotein
PV3 Sabin
B
100575
tskvriymkpkhvr
Polyprotein
PV3 Sabin
B
100576
tssnpsiFYTYGaa
Polyprotein
PV3 Sabin
B
100580
tvddfgvlavrvvn
Polyprotein
PV3 Sabin
B
100583
tvqtrhvvqrrsrs
Polyprotein
PV3 Sabin
B
100585
twqtssnpsifyty
Polyprotein
PV3 Sabin
B
100586
tygaaparisvpyv
Polyprotein
PV3 Sabin
B
100587
tykdtvqlrrklef
Polyprotein
PV3 Sabin
B
100613
vlavrvvndhnptk
Polyprotein
PV3 Sabin
B
100619
vndhnptkvtskvr
Polyprotein
PV3 Sabin
B
100628
vriymkpkhvrvwc
Polyprotein
PV3 Sabin
B
100630
vrvvndhnptkvts
Polyprotein
PV3 Sabin
B
100631
vrVWCPRppravpy
Polyprotein
PV3 Sabin
B
100638
wcprppravpyygp
Polyprotein
PV3 Sabin
B
100644
writykdtvqlrrk
Polyprotein
PV3 Sabin
B
100667
ymkpkhvrVWCPRp
Polyprotein
PV3 Sabin
B
100672
yvglanAYSHFYDg
Polyprotein
PV3 Sabin
B
146178
ayappgaqpptsrk
Polyprotein
PV3 Sabin
B
146181
cgSMMATGkilvay
Polyprotein
PV3 Sabin
B
146248
flfcgSMMATGkil
Polyprotein
PV3 Sabin
B
146311
hqgalgvfaipeyc
Polyprotein
PV3 Sabin
B
146333
ilvayappgaqppt
Polyprotein
PV3 Sabin
B
146390
kftflfcgSMMATG
Polyprotein
PV3 Sabin
B
146494
phqiinlrtnnsat
Polyprotein
PV3 Sabin
B
146496
ppgaqpptsrkeam
Polyprotein
PV3 Sabin
B
146516
ravpyygpgvdyrn
Polyprotein
PV3 Sabin
B
PV-derived epitopes are listed according to increasing IEDB ID number. Further details and reference(s) on each IEDB ID are reported at http://www.immuneepitope.org [17]. bOnly PV-derived epitopes that had been experimentally validated in the human host are reported. cThe twenty PV-derived epitopes (and related IDs) containing PV-pentapeptide(s) absent in the human proteome are in bold, with the pentapeptide(s) absent in the human proteome given in capital.
