Journal of Immunology Research / 2015 / Article / Tab 2

Research Article

Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR

Table 2

Histological assessment of epithelial and inflammatory features in ascending colon (a) and sigmoid colon (b) of PSC patients without or with ulcerative colitis (PSC + UC). Values indicate the mean of scoring system ± SEM.
(a)

FeaturesAscending Colon
ControlPSCPSC + UCPSC versus controlPSC + UC versus controlPSC versus PSC + UC

Architectural change0.1 ± 0.10.4 ± 0.20.7 ± 0.2NSNS
Chronic inflammatory infiltrate0.4 ± 0.11.1 ± 0.21.5 ± 0.3NS
Lamina propria neutrophils and eosinophils0.1 ± 0.10.5 ± 0.21.3 ± 0.3NS
Neutrophils in epithelium0.00.1 ± 0.10.3 ± 0.2NSNSNS
Crypt destruction0.00.00.5 ± 0.4NSNSNS
Erosion or ulceration0.00.4 ± 0.40.3 ± 0.3NSNSNS
Total 0.5 ± 0.22.1 ± 0.43.6 ± 0.8p= 0.025p< 0.0001p= 0.038

(b)

FeatureSigmoid colon
ControlPSCPSC + UCPSC versus controlPSC + UC versus controlPSC versus PSC + UC

Architectural change0.1 ± 0.10.2 ± 0.20.9 ± 0.3NS
Chronic inflammatory infiltrate0.4 ± 0.10.4 ± 0.21.3 ± 0.1NS
Lamina propria neutrophils and eosinophils0.00.1 ± 0.10.9 ± 0.2NS
Neutrophils in epithelium0.00.00.1 ± 0.1NSNSNS
Crypt destruction0.00.00.5 ± 0.4NSNS ()NS
Erosion or ulceration0.00.00.4 ± 0.3NSNSNS
Total0.5 ± 0.20.6 ± 0.32.9 ± 0.4NSp < 0.0001p < 0.0001