Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR

Table 2

Histological assessment of epithelial and inflammatory features in ascending colon (a) and sigmoid colon (b) of PSC patients without or with ulcerative colitis (PSC + UC). Values indicate the mean of scoring system ± SEM.

(a)

Features	Ascending Colon
	Control	PSC	PSC + UC	PSC versus control	PSC + UC versus control	PSC versus PSC + UC
Architectural change	0.1 ± 0.1	0.4 ± 0.2	0.7 ± 0.2	NS		NS
Chronic inflammatory infiltrate	0.4 ± 0.1	1.1 ± 0.2	1.5 ± 0.3			NS
Lamina propria neutrophils and eosinophils	0.1 ± 0.1	0.5 ± 0.2	1.3 ± 0.3	NS
Neutrophils in epithelium	0.0	0.1 ± 0.1	0.3 ± 0.2	NS	NS	NS
Crypt destruction	0.0	0.0	0.5 ± 0.4	NS	NS	NS
Erosion or ulceration	0.0	0.4 ± 0.4	0.3 ± 0.3	NS	NS	NS
Total	0.5 ± 0.2	2.1 ± 0.4	3.6 ± 0.8	p = 0.025	p < 0.0001	p = 0.038

(b)

Feature	Sigmoid colon
	Control	PSC	PSC + UC	PSC versus control	PSC + UC versus control	PSC versus PSC + UC
Architectural change	0.1 ± 0.1	0.2 ± 0.2	0.9 ± 0.3	NS
Chronic inflammatory infiltrate	0.4 ± 0.1	0.4 ± 0.2	1.3 ± 0.1	NS
Lamina propria neutrophils and eosinophils	0.0	0.1 ± 0.1	0.9 ± 0.2	NS
Neutrophils in epithelium	0.0	0.0	0.1 ± 0.1	NS	NS	NS
Crypt destruction	0.0	0.0	0.5 ± 0.4	NS	NS ()	NS
Erosion or ulceration	0.0	0.0	0.4 ± 0.3	NS	NS	NS
Total	0.5 ± 0.2	0.6 ± 0.3	2.9 ± 0.4	NS	p < 0.0001	p < 0.0001