Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205

Figure 5

Interferon signature in genes modulated by fdsc-αDEC. (a) Venn diagram of the genes analyzed by INTERFEROME 2.0 database. (b) Heatmap of 183 “interferon-related” genes modulated upon fdsc-αDEC treatment. Expression values are indicated as logRPKM (reads per kilobase of transcript per million of mapped reads). (c) Heatmap obtained using the online Pscan tool indicating the presence (in red) of transcription factors binding sites (TFBS) within promoters of a selected gene list. In the red box on the left, a detail of such computational analysis is shown.

(a)

(b)

(c)