The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus
Table 2
Genotype and allele analyses of the GABRP gene SNPs in SLE patients and healthy controls.
Position
Genotype/allele
Control (%)
SLE (%)
Odds (95% CI)
rs929763
TT
260 (50.4)
68 (42.5)
1.00
<0.0001
TA
222 (43.0)
61 (38.1)
1.05 (0.71–1.55)
AA
34 (6.6)
31 (19.4)
3.49 (2.00–6.07)
T
742 (71.9)
197 (61.6)
1.00
0.0005
A
290 (28.1)
123 (38.4)
1.60 (1.23–2.08)
rs732157
CC
261 (50.5)
96 (59.3)
1.00
0.05
CT
218 (42.2)
57 (35.2)
0.71 (0.49–1.03)
TT
38 (7.4)
9 (5.5)
0.64 (0.30–1.38)
C
740 (71.6)
249 (76.9)
1.00
0.06
T
294 (28.4)
75 (23.1)
0.76 (0.57–1.02)
rs2303134
AA
518 (98.1)
162 (98.8)
1.00
0.57
AG
10 (1.9)
2 (1.2)
0.64 (0.14–2.95)
GG
0 (0.0)
0 (0)
—
A
1046 (99.1)
326 (99.4)
1.00
0.57
G
10 (0.9)
2 (0.6)
0.64 (0.14–2.94)
rs1063310
CC
233 (45.0)
82 (50.9)
1.00
0.18
CA
237 (45.8)
66 (41.0)
0.79 (0.55–1.15)
AA
48 (9.3)
13 (8.1)
0.77 (0.40–1.49)
C
703 (67.9)
230 (71.4)
1.00
0.23
A
333 (32.1)
92 (28.6)
0.84 (0.64–1.11)
rs3805455
CC
226 (43.9)
63 (40.4)
1.00
0.002
CT
243 (47.2)
65 (41.7)
0.96 (0.65–1.42)
TT
46 (8.9)
28 (17.9)
2.18 (1.26–3.77)
C
695 (67.5)
191 (61.2)
1.00
0.04
T
335 (32.5)
121 (38.8)
1.31 (1.01–1.71)
rs3828619
GG
299 (57.2)
73 (48.7)
1.00
0.003
GA
181 (34.6)
53 (35.3)
1.20 (0.80–1.79)
AA
43 (8.2)
24 (16.0)
2.29 (1.30–4.01)
G
779 (74.5)
199 (66.3)
1.00
0.005
A
267 (25.5)
101 (33.7)
1.48 (1.12–1.95)
Calculated from the translation start site. Logistic regression analyses were used for calculating OR (95% CI; confidence interval). Value was determined by Fisher’s exact test or test from a 2 × 2 contingency table.
