Microbiome and Asthma: What Have Experimental Models Already Taught Us?

Table 2

Models of asthma and microbiome.

Mice strain/antigen	Microbial or exposure evaluation	Effect	Endpoint	References
C57BL/6/nonantigen	Germ-free mice	Increase	Airway resistance and eosinophils in airways	[67]
C57BL/6/OVA	Vancomycin to neonatal mice	Decrease	Bacterial diversity	[69]
		Increase	Inflammation in allergic asthma
BALB/c/OVA	Oral supplementation with Lactobacillus reuteri	Decrease	Allergic airway response	[70]
BALB/c/OVA	Oral supplementation with Bifidobacterium longum	Decrease	Inflammation in allergic asthma	[71]
BALB/c/OVA	Oral supplementation with Enterococcus faecalis FK-23	Suppression	Th17 immune response	[73]
BALB/c/HDM	Lactococcus lactis	Inhibition	Th2 response	[74]
BALB/c/OVA	Heat-shock protein X (HspX) purified from Mycobacterium tuberculosis	Regulation	Th1 immune response	[75]
BALB/c/OVA	BCG	Decrease	Specific-IgE levels, eosinophil, neutrophil, and lymphocyte counts in BAL	[76]
BALB/c/OVA	BCG and interleukin-12 vaccination	Decrease	Allergic airway inflammation	[77]
BALB/c/OVA	Killed Streptococcus pneumoniae	Protection	Asthma	[78]