Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-Müllerian Hormone Receptor II

Figure 4

Inhibition of tumor growth in mice immunized with AMHR2-CD. ID8 tumor growth was inhibited in mice prophylactically vaccinated (a) 15 days, (b) 7 days, or (c) 1 day prior to inoculation of tumor cells. (d) AMHR2-CD vaccination resulted in a significantly decreased overall tumor load as measured by final tumor weight at termination of experiments in mice vaccinated 7 days and 1 day prior to ID8 inoculation. (e) Therapeutic vaccination with AMHR2-CD 60 days after inoculation of ID8 tumors significantly inhibited the growth of established, palpable, and growing ID8 tumors. (f) Prophylactic vaccination of female TgMlSIIR-TAg transgenic mice at 6-7 weeks of age with AMHR2-CD resulted in a highly significant inhibition in growth of autochthonous EOC. (g) Prophylactic AMHR2-CD vaccination of female TgMlSIIR-TAg transgenic mice at 6-7 weeks of age resulted in a highly significant 41.7% mean increased OS compared to control mice vaccinated with CFA alone. Asterisks indicate statistical significance. Error bars show ±SD.

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