The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation

Figure 1

Total anti-β2GP1 IgG in the sera of NHD, PAPS, SLE/APS, and healthy children and the corresponding values. NHD showed significantly lower mOD values than all other cohorts whereas healthy children represented the highest mOD values. Short horizontal lines: mean mOD values of all samples of the cohort. Long broken line: 97.5% quantile of NHD (=738 mOD); NHD = normal healthy donor; PAPS = primary antiphospholipid syndrome; SLE/APS = antiphospholipid syndrome with systemic lupus erythematosus; OD = optical density.