The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation

Table 3

(a) OD values of the anti-β2GP1-IgG subclasses in the investigated cohorts. (b) Comparison ( values) of the OD values of the anti-β2GP1-IgG subclasses.

(a)

	IgG1 [mOD]	IgG2 [mOD]	IgG3 [mOD]	IgG4 [mOD]
NHD	24	64	27	67
Children	69	77	212	210
PAPS	30	85	45	72
SAPS	28	74	55	173
APS	29	81	48	106

(b)

	IgG1	IgG2	IgG3	IgG4
Children versus NHD	<0.0001	n.s.	<0.0001	n.s.
Children versus PAPS	<0.0001.	n.s.	<0.001	n.s.
Children versus SAPS	<0.001	n.s.	<0.001	n.s.
APS versus NHD	n.s.	n.s.	n.s.	n.s.
PAPS versus SAPS	n.s.	n.s.	n.s.	n.s.

OD = optical density 450 nm; PAPS = primary antiphospholipid syndrome; SAPS = secondary antiphospholipid syndrome; APS = PAPS and SAPS; NHD = normal healthy donors; n.s. = not significant.