The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation
Table 3
(a) OD values of the anti-β2GP1-IgG subclasses in the investigated cohorts. (b) Comparison ( values) of the OD values of the anti-β2GP1-IgG subclasses.
(a)
IgG1 [mOD]
IgG2 [mOD]
IgG3 [mOD]
IgG4 [mOD]
NHD
24
64
27
67
Children
69
77
212
210
PAPS
30
85
45
72
SAPS
28
74
55
173
APS
29
81
48
106
(b)
IgG1
IgG2
IgG3
IgG4
Children versus NHD
<0.0001
n.s.
<0.0001
n.s.
Children versus PAPS
<0.0001.
n.s.
<0.001
n.s.
Children versus SAPS
<0.001
n.s.
<0.001
n.s.
APS versus NHD
n.s.
n.s.
n.s.
n.s.
PAPS versus SAPS
n.s.
n.s.
n.s.
n.s.
OD = optical density 450 nm; PAPS = primary antiphospholipid syndrome; SAPS = secondary antiphospholipid syndrome; APS = PAPS and SAPS; NHD = normal healthy donors; n.s. = not significant.