The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation

Table 4

Number (frequency) of seropositive samples of the anti-β2GP1-IgG subclasses.

Number of seropositive samples (>mOD[NHD] + 2 × SD[NHD])
	IgG1; (>2,9 mOD)	IgG2; (>7,9 mOD)	IgG3; (>8,5 mOD)	IgG4; (>31,9 mOD)
NHD ()	0 (0%)	0 (0%)	1 (6%)	1 (6%)
Children ()	13 (100%)	2 (15%)	8 (62%)	2 (15%)
PAPS ()	6 (50%)	5 (42%)	0 (0%)	1 (8%)
SAPS ()	1 (17%)	2 (33%)	0 (0%)	1 (17%)
APS ()	7 (39%)	7 (39%)	0 (0%)	2 (11%)

OD = optical density 450 nm; PAPS = primary antiphospholipid syndrome; SAPS = secondary antiphospholipid syndrome; APS = PAPS and SAPS; NHD = normal healthy donors. The cut-off for seropositivity was calculated from the mean OD of the corresponding anti-β2GP1-IgG subclass of the NHD cohort and its standard deviation (SD) according to the formula: mean OD_[NHD] + 2 × SD_[NHD]. The respective cut-off OD values are indicated in parentheses below the anti-β2GP1-IgG subclasses.