Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes
Table 1
Clinical and laboratory findings of children with type 1 and type 2 autoimmune hepatitis.
AIH-1
AIH-2
Clinical features
Age onset; median (min–max)
8.2 (1.6–15.2)
4.8 (11.1–9.0)
Sex; (F/M)
78/39
21/3
Onset; (acute/insidious)
98/19
20/4
Concurrent autoimmune disease1; (%)
15 (12.8)
3 (12.5)
Autoimmune diseases in relatives2; (%)
23 (19.6)
11 (45.8)
Laboratory findings
AA: type 1, SMA/ANA/SMA + ANA; type 2, LKM ()
64/7/46
24
Alanine aminotransferase IU/L (× upper normal limit); median (min-max)
18 (2–128)
28 (4–85)
Albumin g/dL; median (min-max)
3.3 (2.2–5.1)
3.5 (2.6–4.7)
Bilirubin mg/dL; median (min-max)
3.3 (0.3–27.2)
5.8 (0.6–35)
γ-globulin g/dL; median (min-max)
3.4 (0.9–6.3)
3.3 (0.9–4.8)
IgE IU/mL; median (min-max)
96 (11–2245)
65 (6–560)
Histological features
Cirrhosis; (yes/no)
64/41
10/10
Not done
12
4
F = female; M = male; AA = autoantibody; SMA = smooth muscle antibody; ANA = antinuclear antibody; LKM = Liver Kidney Microsomal; = number of individuals. Normal albumin = 3.5–5.0 g/dL; normal bilirubin ≤ 1.1 mg/dL; normal γ-globulin = 0.7–1.6 g/dL; normal IgE = 20–100 IU/mL. 1Vitiligo, thyroiditis, diabetes mellitus, psoriasis, or Behçet’s disease. 2First degree relatives.
