Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes

Table 2

Semiquantitative assessment of the histopathological variables by serum IgE levels in AIH-1 and AIH-2 patients.

Histopathological variables	Score	AIH-1		AIH-2
		IgE		IgE
		Normal	Increased	Normal	Increased
		= 27 (%)	= 33 (%)	= 11 (%)	= 2 (%)
Structural changes	1-2	2 (7)	1 (3)	1 (9)	0 (0)
	3	2 (7)	2 (6)	1 (9)	1 (50)
	4	23 (86)	30 (91)	9 (82)	1 (50)
Portal inflammation	1-2	8 (30)	11 (33)	5 (45)	0 (0)
	3	15 (55)	11 (33)	4 (36)	1 (50)
	4	4 (15)	11 (33)	2 (18)	1 (50)
Periportal inflammation	1-2	6 (22)	7 (21)	3 (27)	0 (0)
	3	11 (41)	10 (30)	3 (27)	1 (50)
	4	10 (37)	19 (55)	5 (46)	1 (50)
Panacinar necrosis	Present	12 (44)	21 (64)	3 (27)	2 (100)
Plasmocytes	Present	20 (74)	27 (82)	8 (73)	1 (50)
Eosinophils	Present	16 (59)	19 (58)	7 (64)	1 (50)
Rosettes	Present	24 (89)	29 (88)	10 (91)	2 (100)

1 = minimal portal fibrosis; 2 = moderate portal fibrosis; 3 = bridging fibrosis; 4 = cirrhosis.