Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes

Table 4

Genotype and allele frequencies of IL13 rs20541 and IL4RA rs1805011 in children with type 1 autoimmune hepatitis (AIH-1) and in healthy controls (HC).

	AIH-1	HC		OR	95% CI
	= 117	= 160
IL13 rs20541	(%)	(%)
Genotype
AA	18 (15)	6 (4)
AG	37 (32)	60 (38)	0.003
GG	62 (53)	94 (58)
AA versus AG+GG			<0.001	4.62	1.77–12.04
Allele
A	73 (31)	72 (23)	0.024	1.55	1.06–2.27
G	161 (69)	248 (77)
IL4RA rs1805011	= 88	= 212
Genotype
AA	41 (47)	40 (19)
AG	37 (42)	129 (61)	<0.001
GG	10 (11)	43 (20)
AA versus AG+GG			<0.001	3.75	2.18–6.45
Allele
A	119 (68)	209 (49)	<0.001	2.15	1.49–3.11
G	57 (32)	215 (51)

IL13 codon 110 (rs20541): A allele = Q (glutamic acid) and G allele = R (arginine); IL4RA codon 50 (rs1805011): A allele = I (isoleucine) and G allele = V (valine); = number of individuals; OR = odds ratio; CI = confidence interval.