Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt

Table 2

Crude and adjusted odds ratio for the association between single nucleotide polymorphisms and poor prognosis.

	Minor allele	Crude
		OR (95% CI)	value	OR (95% CI)	value
All categories
TNFA1P3/20 rs6920220 A/G	A	1.53 (1.01–2.33)	0.0436	1.67 (0.98–2.83)	0.0579
TRAF1/C5 rs3761847 A/G	G	1.49 (1.00–2.21)	0.0491	1.96 (1.17–3.3)	0.0110
PTPN2 rs7234029 A/G	G	1.86 (1.17–2.95)	0.0085	1.75 (0.99–3.1)	0.0540
Polyarticular categories
CTLA4 rs3087243 A/G	A	1.98 (1.14–3.45)	0.0153	2.9 (1.39–6.08)	0.0047
PTPN2 rs7234029 A/G	G	3.08 (1.53–6.19)	0.0016	3.3 (1.48–7.37)	0.0035

Clinical covariates included disease category, DMARD treatment, and physician VAS. Disease category was omitted from the model for the polyarticular categories of JIA.
OR: odds ratio; SNPs: single nucleotide polymorphisms. values < 0.05 were considered statistically significant.