Journal of Immunology Research

Research Article

EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses

Table 3

Shared orthopoxvirus proteins with transmembrane and/or leader sequences.


VARV GI\|ORF	MPXV GI\|ORF	CPXV GI\|ORF	VACV GI\|ORF	IDEN¹ (%)	TM²	LEAD³	EXP⁴	LOCATION⁵

GI:439084\|B6R	GI:17975080\|B6R	GI:20153177\|V190	GI:335549\|B5R	93.1	Yes	Yes	L	EEV membrane
GI:439016\|F8L	GI:17975018\|E8L	GI:20153106\|V119	GI:335455\|D8L	94.7	Yes	No	L	IMV membrane
GI:438990\|H9R	GI:17974992\|G10R	GI:20153081\|V094	GI:335423\|G9R	98.1	Yes	No	L	U
GI:438919\|D4R	GI:17974919\|D3R	GI:20153007\|V020	GI:335333\|C11R	88.8	Yes	Yes	U	U
GI:439085\|B7R	GI:17975081\|B7R	GI:20153178\|V191	GI:335550\|B6R	93.1	Yes	No	U	U
GI:439035\|A14L	GI:17975037\|A14L	GI:20153125\|V138	GI:335483\|A13L	88.6	Yes	No	L	IMV membrane
GI:438946\|C8L	GI:17974949\|C10L	GI:20153036\|V049	GI:335366\|F4L	97.6	Yes	No	E	U
GI:438977\|K5L	GI:17974979\|I5L	GI:20153068\|V081	GI:335409\|I5L	94.9	Yes	No	L	IMV membrane
GI:438967\|E8R	GI:17974969\|F7R	GI:20153058\|V071	GI:335395\|E8R	97.4	Yes	No	L	U
GI:439004\|I3L	GI:17975006\|H3L	GI:20153094\|V107	GI:335438\|H3L	95.8	Yes	No	L	IMV membrane
GI:439014\|F6R	GI:17975016\|E6R	GI:20153104\|V117	GI:335453\|D6R	99.0	Yes	No	L	U
GI:439003\|I2R	GI:17975005\|H2R	GI:20153093\|V106	GI:335437\|H2R	99.2	Yes	No	L	U
GI:439056\|A35L	GI:17975057\|A34L	GI:20153148\|V161	GI:335506\|A32L	98.1	Yes	No	L	U
GI:439000\|L5L	GI:17975002\|L5L	GI:20153090\|V103	GI:335433\|J5L	98.1	Yes	No	L	U
GI:439058\|A37R	GI:17975059\|A36R	GI:20153150\|V163	GI:335509\|A34R	98.1	Yes	No	L	EEV membrane
GI:438991\|M1R	GI:17974993\|M1R	GI:20153082\|V095	GI:335424\|L1R	99.2	Yes	No	L	IMV membrane
GI:439057\|A36R	GI:17975058\|A35R	GI:20153149\|V162	GI:335508\|A33R	93.0	Yes	No	E	EEV membrane
GI:438951\|C13L	GI:17974954\|C15L	GI:20153041\|V054	GI:335373\|F9L	97.5	Yes	No	L	U
GI:439038\|A17L	GI:17975040\|A17L	GI:20153129\|V142	GI:335486\|A16L	97.0	Yes	No	L	U
GI:438974\|K2L	GI:17974976\|I2L	GI:20153065\|V078	GI:335405\|I2L	99.3	Yes	No	L	U
GI:439008\|I7R	GI:17975010\|H7R	GI:20153098\|V111	GI:335442\|H7R	95.2	Yes	No	L	U
GI:438982\|H3L	GI:17974984\|G2L	GI:20153073\|V086	GI:335414\|G3L	95.8	Yes	No	L	U
GI:439042\|A22L	GI:17975044\|A21L	GI:20153134\|V147	GI:335490\|A21L	96.9	Yes	No	U	U
GI:439059\|A38R	GI:17975061\|A38R	GI:20153152\|V165	GI:335512\|A36R	92.3	Yes	No	E, L	EEV membrane
GI:439031\|A10L	GI:17975033\|A10L	GI:20153121\|V134	GI:335476\|A9L	89.0	Yes	Yes	E, L	U
GI:439033\|A12R	GI:17975035\|A12R	GI:20153123\|V136	GI:335481\|A11R	98.5	Yes	No	L	U
GI:439036\|A15L	GI:17975038\|A15L	GI:20153126\|V139	GI:335484\|A14L	97.8	Yes	No	L	IMV membrane
GI:439067\|A46R	GI:17975066\|A43R	GI:20153159\|V172	GI:335522\|A43R	92.3	Yes	Yes	U	U
GI:439039\|A18L	GI:17975041\|A18L	GI:20153130\|V143	GI:335487\|A17L	98.0	Yes	No	L	IMV membrane
GI:439077\|J7R	GI:17975076\|B2R	GI:20153172\|V185	GI:335539\|A56R	82.1	Yes	Yes	E, L	EEV membrane
GI:439062\|A41L	GI:17975063\|A40L	GI:20153155\|V168	GI:335516\|A38L	94.7	Yes	Yes	U	U

Table shows GenBank identification numbers (GI) and open reading frame names (ORF) for VARV: strain Bangladesh-1975, MPXV: strain Zaire-96-I-16, CPXV: strain Brighton Red, and VACV: strain Copenhagen. ¹IDEN: average identity between the selected proteins. ²TM: transmembrane. ³LEAD: leader signal. ⁴EXP: temporal expression (E: early, I: intermediate, and L: late). ⁵LOCATION: location. Proteins known to induce protective immunity (see Table 2). Annotations were obtained as indicated elsewhere in Section 2. U: information not found.