Respiratory Syncytial Virus Nonstructural Proteins Upregulate SOCS1 and SOCS3 in the Different Manner from Endogenous IFN Signaling

Figure 6

Model of RSV NS proteins activated SOCS1 and SOCS3 independent of endogenous IFN signaling. RSV replication and transcription releases NS1 and NS2 which upregulate SOCS1 and SOCS3 expression inhibit endogenous IFN-induced products and exogenous IFN-inducible signaling. NS1 induced SOCS1 and SOCS3 expression, while NS2 only induced SOCS1. Albeit both NS and type I IFN upregulate SOCS1 and SOCS3, NS suppressed the IFN-induced genes as well as the TLR3-dependent chemokines expression.