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Journal of Immunology Research
Volume 2015, Article ID 738547, 11 pages
http://dx.doi.org/10.1155/2015/738547
Research Article

Respiratory Syncytial Virus Nonstructural Proteins Upregulate SOCS1 and SOCS3 in the Different Manner from Endogenous IFN Signaling

1Department of Pediatrics, Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan 430071, China
2Department of Anatomy, School of Medicine, Wuhan University, Donghu Road 169, Wuhan 430071, China
3Institute of Virology, College of Life Science, Wuhan University, Wuhan 430072, China

Received 2 March 2015; Revised 13 June 2015; Accepted 21 June 2015

Academic Editor: Francois Villinger

Copyright © 2015 Junwen Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Nair, D. J. Nokes, B. D. Gessner et al., “Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis,” The Lancet, vol. 375, no. 9725, pp. 1545–1555, 2010. View at Publisher · View at Google Scholar
  2. J. E. Evans, P. A. Cane, and C. R. Pringle, “Expression and characterisation of the NS1 and NS2 proteins of respiratory syncytial virus,” Virus Research, vol. 43, no. 2, pp. 155–161, 1996. View at Publisher · View at Google Scholar
  3. B. Bossert and K. Conzelmann, “Respiratory syncytial virus (RSV) nonstructural (NS) proteins as host range determinants: a chimeric bovine RSV with NS genes from human RSV is attenuated in interferon-competent bovine cells,” Journal of Virology, vol. 76, no. 9, pp. 4287–4293, 2002. View at Publisher · View at Google Scholar
  4. J. Schlender, B. Bossert, U. Buchholz, and K. K. Conzelmann, “Bovine respiratory syncytial virus nonstructural proteins NS1 and NS2 cooperatively antagonize alpha/beta interferon-induced antiviral response,” Journal of Virology, vol. 74, no. 18, pp. 8234–8242, 2000. View at Publisher · View at Google Scholar
  5. B. Bossert, S. Marozin, and K. K. Conzelmann, “Nonstructural proteins NS1 and NS2 of bovine respiratory syncytial virus block activation of interferon regulatory factor 3,” Journal of Virology, vol. 77, no. 16, pp. 8661–8668, 2003. View at Publisher · View at Google Scholar
  6. K. M. Spann, K. Tran, B. Chi, R. L. Rabin, and P. L. Collins, “Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 of human respiratory syncytial virus in human epithelial cells and macrophages,” Journal of Virology, vol. 78, no. 8, pp. 4363–4369, 2004. View at Publisher · View at Google Scholar
  7. K. M. Spann, K. C. Tran, and P. L. Collins, “Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-κB, and proinflammatory cytokines,” Journal of Virology, vol. 79, no. 9, pp. 5353–5362, 2005. View at Publisher · View at Google Scholar
  8. M. S. Lo, R. M. Brazas, and M. J. Holtzman, “Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness,” Journal of Virology, vol. 79, no. 14, pp. 9315–9319, 2005. View at Publisher · View at Google Scholar
  9. M. Ramaswamy, L. Shi, S. M. Varga, S. Barik, M. A. Behlke, and D. C. Look, “Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction,” Virology, vol. 344, no. 2, pp. 328–339, 2006. View at Publisher · View at Google Scholar
  10. W. Zhang, H. Yang, X. Kong et al., “Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene,” Nature Medicine, vol. 11, no. 1, pp. 56–62, 2004. View at Publisher · View at Google Scholar
  11. H. Yoshikawa, K. Matsubara, G. Qian et al., “SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity,” Nature Genetics, vol. 28, no. 1, pp. 29–35, 2001. View at Publisher · View at Google Scholar
  12. T. Kawai and S. Akira, “Toll-like receptor and RIG-1-like receptor signaling,” Annals of the New York Academy of Sciences, vol. 1143, no. 1, pp. 1–20, 2008. View at Publisher · View at Google Scholar
  13. W. S. Alexander and D. J. Hilton, “The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response,” Annual Review of Immunology, vol. 22, pp. 503–529, 2004. View at Google Scholar
  14. L. N. Akhtar and E. N. Benveniste, “Viral exploitation of host SOCS protein functions,” Journal of Virology, vol. 85, no. 5, pp. 1912–1921, 2011. View at Publisher · View at Google Scholar
  15. H. Kato, O. Takeuchi, S. Sato et al., “Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses,” Nature, vol. 441, no. 7089, pp. 101–105, 2006. View at Publisher · View at Google Scholar
  16. S. Jensen and A. R. Thomsen, “Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion,” Journal of Virology, vol. 86, no. 6, pp. 2900–2910, 2012. View at Publisher · View at Google Scholar
  17. B. D. Rudd, E. Burstein, C. S. Duckett, X. Li, and N. W. Lukacs, “Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression,” Journal of Virology, vol. 79, no. 6, pp. 3350–3357, 2005. View at Publisher · View at Google Scholar
  18. Y. M. Loo, J. Fornek, N. Crochet et al., “Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity,” Journal of Virology, vol. 82, no. 1, pp. 335–345, 2008. View at Publisher · View at Google Scholar
  19. B. D. Rudd, J. J. Smit, R. A. Flavell et al., “Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection,” The Journal of Immunology, vol. 176, no. 3, pp. 1937–1942, 2006. View at Publisher · View at Google Scholar
  20. A. Pichlmair, O. Schulz, C. P. Tan et al., “RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates,” Science, vol. 314, no. 5801, pp. 997–1001, 2006. View at Publisher · View at Google Scholar
  21. H. Kato, O. Takeuchi, E. Mikamo-Satoh et al., “Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5,” The Journal of Experimental Medicine, vol. 205, no. 7, pp. 1601–1610, 2008. View at Publisher · View at Google Scholar
  22. X. Bao, H. Indukuri, T. Liu et al., “IKKε modulates RSV-induced NF-κB-dependent gene transcription,” Virology, vol. 408, no. 2, pp. 224–231, 2010. View at Publisher · View at Google Scholar
  23. F. Yoboua, A. Martel, A. Duval, E. Mukawera, and N. Grandvaux, “Respiratory syncytial virus-mediated NF-κB p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKKβ,” Journal of Virology, vol. 84, no. 14, pp. 7267–7277, 2010. View at Publisher · View at Google Scholar
  24. J. Pothlichet, M. Chignard, and M. Si-Tahar, “Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway,” The Journal of Immunology, vol. 180, no. 4, pp. 2034–2038, 2008. View at Publisher · View at Google Scholar
  25. E. Pauli, M. Schmolke, T. Wolff et al., “Influenza A virus inhibits type I IFN signaling via NF-κB-dependent induction of SOCS-3 expression,” PLoS Pathogens, vol. 4, no. 11, 2008. View at Publisher · View at Google Scholar
  26. C. M. Oshansky, T. M. Krunkosky, J. Barber, L. P. Jones, and R. A. Tripp, “Respiratory syncytial virus proteins modulate suppressors of cytokine signaling 1 and 3 and the type I interferon response to infection by a toll-like receptor pathway,” Viral Immunology, vol. 22, no. 3, pp. 147–161, 2009. View at Publisher · View at Google Scholar
  27. Z. Ling, K. C. Tran, and M. N. Teng, “Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I,” Journal of Virology, vol. 83, no. 8, pp. 3734–3742, 2009. View at Publisher · View at Google Scholar
  28. P. Nakhaei, T. Mesplede, M. Solis et al., “The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation,” PLoS Pathogens, vol. 5, no. 11, Article ID e1000650, 2009. View at Publisher · View at Google Scholar
  29. C. Motz, K. M. Schuhmann, A. Kirchhofer et al., “Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling,” Science, vol. 339, no. 6120, pp. 690–693, 2013. View at Publisher · View at Google Scholar
  30. A. Yoshimura, T. Naka, and M. Kubo, “SOCS proteins, cytokine signalling and immune regulation,” Nature Reviews Immunology, vol. 7, no. 6, pp. 454–465, 2007. View at Publisher · View at Google Scholar
  31. S. Boyapalle, T. Wong, J. Garay et al., “Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection,” PLoS ONE, vol. 7, no. 2, Article ID e29386, 2012. View at Publisher · View at Google Scholar
  32. S. Swedan, A. Musiyenko, and S. Barik, “Respiratory syncytial virus nonstructural proteins decrease levels of multiple members of the cellular interferon pathways,” Journal of Virology, vol. 83, no. 19, pp. 9682–9693, 2009. View at Publisher · View at Google Scholar
  33. X. Xu, J. Zheng, K. Zheng, Y. Hou, F. Zhao, and D. Zhao, “Respiratory syncytial virus NS1 protein degrades STAT2 by inducing SOCS1 expression,” Intervirology, vol. 57, pp. 65–73, 2014. View at Publisher · View at Google Scholar
  34. K. Hashimoto, K. Ishibashi, K. Ishioka et al., “RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules,” Virology, vol. 391, no. 2, pp. 162–170, 2009. View at Publisher · View at Google Scholar
  35. P. Liu, M. Jamaluddin, K. Li, R. P. Garofalo, A. Casola, and A. R. Brasier, “Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells,” Journal of Virology, vol. 81, no. 3, pp. 1401–1411, 2007. View at Publisher · View at Google Scholar
  36. J. Elliott, O. T. Lynch, Y. Suessmuth et al., “Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase,” Journal of Virology, vol. 81, no. 7, pp. 3428–3436, 2007. View at Publisher · View at Google Scholar
  37. S. Swedan, J. Andrews, T. Majumdar, A. Musiyenko, and S. Barik, “Multiple functional domains and complexes of the two nonstructural proteins of human respiratory syncytial virus contribute to interferon suppression and cellular location,” Journal of Virology, vol. 85, no. 19, pp. 10090–10100, 2011. View at Publisher · View at Google Scholar
  38. M. L. Hastie, M. J. Headlam, N. B. Patel et al., “The human respiratory syncytial virus nonstructural protein 1 regulates type I and type II interferon pathways,” Molecular & Cellular Proteomics, vol. 11, pp. 108–127, 2012. View at Google Scholar
  39. Y. M. Abbas, A. Pichlmair, M. W. Górna, G. Superti-Furga, and B. Nagar, “Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins,” Nature, vol. 494, no. 7435, pp. 60–64, 2013. View at Publisher · View at Google Scholar
  40. T. Aoshi, S. Koyama, K. Kobiyama, S. Akira, and K. J. Ishii, “Innate and adaptive immune responses to viral infection and vaccination,” Current Opinion in Virology, vol. 1, no. 4, pp. 226–232, 2011. View at Publisher · View at Google Scholar
  41. J. Pothlichet, I. Meunier, B. K. Davis et al., “Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells,” PLoS Pathogens, vol. 9, no. 4, Article ID e1003256, 2013. View at Publisher · View at Google Scholar
  42. J. Wang, M. P. Nikrad, T. Phang et al., “Innate immune response to influenza A virus in differentiated human alveolar type II cells,” American Journal of Respiratory Cell and Molecular Biology, vol. 45, no. 3, pp. 582–591, 2011. View at Publisher · View at Google Scholar
  43. R. Goswami, T. Majumdar, J. Dhar et al., “Viral degradasome hijacks mitochondria to suppress innate immunity,” Cell Research, vol. 23, no. 8, pp. 1025–1042, 2013. View at Publisher · View at Google Scholar
  44. L. Gatto, C. Berlato, V. Poli et al., “Analysis of SOCS-3 promoter responses to interferon γ,” The Journal of Biological Chemistry, vol. 279, pp. 13746–13754, 2004. View at Google Scholar
  45. Y. Tan, D. Peng, C. Chen, and X. Qin, “Nonstructural protein-1 of respiratory syncytial virus regulates HOX gene expression through interacting with histone,” Molecular Biology Reports, vol. 40, no. 1, pp. 675–679, 2013. View at Publisher · View at Google Scholar
  46. M. Cai, M. Li, K. Wang et al., “The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the toll-Like receptor 2 and MyD88/TRAF6-dependent signaling pathway,” PLoS ONE, vol. 8, no. 1, Article ID e54586, 2013. View at Publisher · View at Google Scholar