Genetic Factors in Systemic Lupus Erythematosus: Contribution to Disease Phenotype

Table 1

Genetic variants associated with disease manifestations.

Disease phenotypes	Genetic variants associated with related SNPs
Skin involvement	ITGAM rs1143679; FCGR2A rs1801274; IL-6 174G/C; VDR rs1168268
Serositis	TRAF3IP2 rs33980500, rs13190932, and rs13196377; PTPN2 rs2542151
Kidney involvement	HLADR2, HLADR3 rs2187668; STAT4 rs7574865, rs11889341, rs7568275, and rs7582694; ITGAM rs1143683, rs1143679; IRF5 rs2004640, rs2079197, and rs10488631; IRF7 rs4963128; TNFS4 rs2205960; DNAse I Q222R
Neurologic disorder	TREX1 rs922075, rs6776700, rs6442123, rs2242150, and rs11797
Joint involvement	ITGAM rs1143679; FGCR2A, FCGR3A; VDR rs3890733; Mir146a rs2910164
Hematological features	IL-21 rs907715; STK17A haplotype TAGTC
Immunologic disorders	Anti-dsDNA; HLADR2, HLADR3 rs2187668; STAT4 rs7582694, rs7574865; ITGAM rs1143679, rs9888739; IRF5 rsrs10488631; SSA/SSB; ITGAM rs1143679; IRF7 rs4963128; HCP5 rs3099855; HLADR3 rs2187668; RNP; ITGAM rs1143679; Sm; ITGAM rs7574865; aCL; HCP5 rs3099844; C3 reduction; Mir146a rs2910164; C4 reduction; TRAF3IP2 rs33980500