IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation

Figure 8

Correlation between IFI16 and NF-κB target gene expression in normal B-cell subsets. Expression of NF-κB target genes was studied in the different B-cell populations (a). A mean of the normalized expression values of the considered target genes was calculated and defined as the NF-κB signature. Cases with NF-κB signature values below 0 were considered to have an inactive pathway; cases with values above 0 were considered as having an active pathway. IFI16 mRNA expression levels were then analyzed in the two groups (b). Significantly higher IFI16 mRNA levels were detected in normal samples with an active NF-κB signature (). Specifically, germinal center cells and plasma cells (low NF-κB signature) were compared to naïve and memory cells (high NF-κB signature).

(a)

(b)