Automatic Generation of Validated Specific Epitope Sets

Table 1

Example of a dataset reduction of MHC class II epitopes.

(a) Epitopes before being processed by the clustering tool; epitopes forming a potential consensus sequence or cluster are in bold

Epitope/cluster	RF score	Assay score
MLVLLVAVLVTAVYAFVHA	0.67	8
IQGNVTIHSLLDEGK	0.66	8
VPSPSMGRDIKVQFQSGGAN	0.65	12
NVTSIHSLLDEGKPT	0.63	12
QGNVTIHSLLDEGKPT	0.59	12
AQAAVVRFQEAANKQKQELD	0.47	12
GNVTSIHSLLDEG	0.46	4
FAGIEAAASAIQGNV	0.42	12

(b) The cluster generated by combining the sequences and associated information is in bold

Epitope/cluster	RF score	Assay score
MLVLLVAVLVTAVYAFVHA	0.67	8
VPSPSMGRDIKVQFQSGGAN	0.65	12
IQGNVTIHSLLDEGKPT	0.57	12
AQAAVVRFQEAANKQKQELD	0.47	12
FAGIEAAASAIQGNV	0.42	12