Correlation between Genetic Variations and Serum Level of Interleukin 28B with Virus Genotypes and Disease Progression in Chronic Hepatitis C Virus Infection
Table 1
Basic characteristics of all subjects included in this study.
Variable
Chronic HCV
Cirrhosis+HCC
Control
value
Age (yrs.)
48.00 (36.00–57.00)
57.00 (48.00–63.00)
29.00 (24.00–36.00)
<0.000
Sex
Male count (%)
274 (50.5%)
94 (51.4%)
568 (94.7%)
<0.000
Female count (%)
269 (49.5%)
89 (48.6%)
32 (5.3%)
BMI
31.88 (26.53–71.43)
28.72 (24.57–34.13)
0.014
Platelet count (109/L)
216.00 (169.00–284.50)
148.00 (102.50–200.50)
<0.000
Bil (umol/L)*
13.21 ± 26.18
25.07 ± 73.34
<0.000
ALT (IU/L)*
74.53 ± 66.9
83.66 ± 62.47
0.766
AST (IU/L)*
45.07 ± 40.299
75.16 ± 57.16
<0.000
AFP (ug/L)*
6.36 ± 22.03
15.97 ± 27.14
<0.000
ALP (IU/L)*
106.30 ± 53.07
122.65 ± 76.77
0.004
Creatinine (umol/L)*
110 ± 151.31
97.72 ± 127.30
0.074
HCV load IU/mL ()
5.80 (4.788–6.41)
6.025 (5.49–6.44)
0.511
HCV genotypes
4 (357)
249 (70%)
108 (30%)
<0.0001
1 (148)
115 (77.7%)
33 (22.3%)
Others (173)
154 (89%)
19 (11%)
BMI: body mass index; Bil: bilirubin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; AFP: -fetoprotein, ALP: alkaline phosphatase. *Values are expressed as mean ± SD, values are expressed as median-interquartile range (25th–75th), includes genotypes 2, 3, and untypable genotypes. Nonparametric tests, Chi-squared tests, and independent -tests.
