Journal of Immunology Research / 2015 / Article / Fig 3

Research Article

The Peptide Vaccine Combined with Prior Immunization of a Conventional Diphtheria-Tetanus Toxoid Vaccine Induced Amyloid β Binding Antibodies on Cynomolgus Monkeys and Guinea Pigs

Figure 3

Effects of antiserum from cynomolgus monkeys vaccinated with RGD-DiTox20-KK-Aβ1–13 peptides or vehicle on Aβ-induced cytotoxicity of PC12 cells. The effects of the anti-Aβ monoclonal antibodies (positive control: black bar) and nonspecific immunoglobulin (gray bar) on the cytotoxicity of Aβ peptides (base control of cytotoxicity: white bar) are indicated (a). The effects of the serum of Aβ1–42 peptide-immunized monkey (0.5 mg/head low dose: black bar, and 2.5 mg/head high dose: gray bar) on the cytotoxic Aβ42 peptides (buffer control: white bar) are indicated.

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