Journal of Immunology Research / 2015 / Article / Tab 1

Review Article

Extracellular Vesicles: Role in Inflammatory Responses and Potential Uses in Vaccination in Cancer and Infectious Diseases

Table 1

Major components of extracellular vesicles and their functions described.

OriginMoleculeFunctionReference

TumorMHC I and IIAntigen presentation[18]
miRNA and mRNAOncogenic activity, drug resistance, and metastasis angiogenesis[1922]
CXCR4 and MMP-9Invasion and migration [23]
TrkB, EGFR, and TES complexAngiogenesis[24]
Rab22A, Pabp1, and PSAMetastasis[2527]
CD40, CD80, CD86, and CD54Immunity[28]
GTPase and Rab27aUpregulated immune system and inhibited tumor growth[29]

BacteriaOmpQ and pertactinImmunogenic[30]
Gene transferCommunication[31]
GentamycinCell death[32]
RNAsCommunication[33, 34]

ProtozoatGPI-mucinActivation[35]
Tc85Invasion/adhesion[36]
gp63 and LPGVirulence factor[3739]
TSVirulence factor[40, 41]

Fungi-galImmunogenic[42]
GXM and GlcCerVirulence factor[4345]

Eukaryotic mammalian cellsMHC I and IIAntigen presentation[2]
FasLImmune suppression[13]

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