Evaluation of Anti-TBGL Antibody in the Diagnosis of Tuberculosis Patients in China
Table 1
Clinical and demographic information of study patients.
Parameter
Value for group
PTB
ETB
AIDS-TB
HC
Number of patients
45
26
16
58
Age (years [mean ± SD])
Sex (number of males/number of females)
35/10
11/15
12/3
41/17
Classification (number)
New case
28
21
12
0
Relapsed case
11
4
3
0
Unknown
6
1
1
0
Comorbidities
Chronic diseases
27/17 (61.4)
9/17 (34.6)
5/9 (33.3)
n.a
Symptoms
Cough & chest discomfort
38/6 (86.4)
12/12 (50.0)
8/7 (53.3)
0/58 (0.0)
Fever
14/30 (31.8)
15/9 (62.5)
11/4 (73.3)
0/58 (0.0)
Hemoptysis
12/32 (27.3)
1/23 (4.2)
0/16 (0.0)
0/58 (0.0)
Expectoration
23/21 (52.3)
5/20 (20.0)
0/16 (0.0)
0/58 (0.0)
Chest X-ray
Cavitation
24/20 (54.5)
0/26 (0.0)
0/16 (0.0)
0/58 (0.0)
Pleural effusion
15/29 (34.1)
10/15 (40.0)
5/9 (35.7)
0/58 (0.0)
Lymphadenopathy (BHL)
3/41 (6.8)
3/22 (12.0)
3/11 (21.4)
0/58 (0.0)
Bronchiectasis
13/31 (29.5)
2/23 (8.0)
0/14 (0.0)
0/58 (0.0)
TB screening test
Smear
23/18 (56.1)
7/14 (33.3)
9/4 (69.2)
0/58 (0.0)
TST
11/6 (64.7)
7/3 (70.0)
1/0 (100.0)
0/58 (0.0)
TB antibody
Anti-TBGL IgG
31/14 (68.9)
12/14 (46.2)
1/15 (6.3)
11/47 (19.0)
Anti-TBGL IgA
21/23 (46.7)
4/22 (15.4)
2/14 (12.5)
6/52 (10.3)
Others mean ± std
Blood IgA (g/L)
n.a
n.a
Blood IgG (g/L)
n.a
n.a
Blood IgM (g/L)
n.a
n.a
CRP (mg/L)
n.a
n.a
CD4 count
n.a
n.a
n.a
CD8 count
n.a
n.a
n.a
PTB = pulmonary TB; ETB = extrapulmonary TB; HC = healthy control. aThe number of positive subjects/the number of negative subjects (percentage of positive subjects). bSignificant difference between PTB and HC samples (). cSignificant difference between PTB and AIDS-TB samples (). dSignificant difference between PTB and ETB samples (). eSignificant difference between ETB and HC samples ().
