Inhibins Tune the Thymocyte Selection Process by Regulating Thymic Stromal Cell Differentiation

Figure 2

MHCII and CD86 expression in cDCs are reduced in thymus of Inhα^−/− mice. (a) Representative flow cytometry dot plots and frequency of thymic cDCs defined as CD11c⁺ MHCII⁺ cells. For the MHCII (b), CD80 (c), and CD86 (c) expression, MFI was determined and reported as relative expression compared to Inhα^+/+ mice. A significant reduction was observed for MHCII () and CD86 () expression in Inhα^−/− thymic cDCs. One representative example of a total of 13 mice is shown (Inhα^+/+, ; Inhα^−/−, ) from 3 independent experiments. Values are expressed as mean ± SEM. Statistical significance: .

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