Downmodulation of Vaccine-Induced Immunity and Protection against the Intracellular Bacterium Francisella tularensis by the Inhibitory Receptor FcγRIIB

Table 1

Relative differences in Ab levels between naïve WT and naïve FcγRIIB KO mice.

Experimental group	Response measured	WT mice (median response)	KO mice (median response)	Fold change^c
Naïve before challenge	Total serum IgM^a	451	441	1.0
	Total serum IgG^a	758	1134	1.5^*
	Total serum IgA^a	14	20	1.4
	Ft-specific serum IgM^b	88	85	1.0
	Ft-specific serum IgG^b	33	92	2.8

μg/mL of Ab.
^bAb titer.
^cFold change was caculated by deviding KO mice (median response) by WT mice (median response).
^* < 0.05.