Aeromonas salmonicida Infection Only Moderately Regulates Expression of Factors Contributing to Toll-Like Receptor Signaling but Massively Activates the Cellular and Humoral Branches of Innate Immunity in Rainbow Trout (Oncorhynchus mykiss)
Table 2
Expression profiles of various cytokines in selected tissues of rainbow trout at different time points after infection.
Gene symbol
Tissues
Fold change values at time points after infection relative to control
6 h
12 h
24 h
48 h
72 h
il1b
Spleen
39.35 ± 12.98
47.80 ± 13.94
7.54 ± 2.33
8.89 ± 2.64
3.63 ± 1.04
Head kidney
180.12 ± 75.62
393.18 ± 95.32
17.50 ± 7.97
17.39 ± 5.72
28.38 ± 8.11
Liver
68.47 ± 26.01
151.60 ± 42.63
19.35 ± 6.24
22.21 ± 8.50
81.23 ± 32.69
Thymus
3.36 ± 0.73
9.74 ± 2.93
2.00 ± 0.57
1.63 ± 0.35
2.75 ± 0.66
tnf
Spleen
8.68 ± 4.55
7.76 ± 2.34
−1.16 ± 0.37
1.12 ± 0.30
1.82 ± 0.52
Head kidney
2.06 ± 0.70
11.94 ± 4.32
−1.18 ± 0.53
−1.31 ± 0.26
1.64 ± 0.38
Liver
21.10 ± 13.46
11.58 ± 4.93
3.74 ± 1.68
8.50 ± 4.33
10.88 ± 5.68
Thymus
1.18 ± 0.28
2.10 ± 0.74
−1.27 ± 0.36
−1.13 ± 0.15
1.54 ± 0.25
il8
Spleen
27.85 ± 11.11
14.92 ± 4.55
4.30 ± 1.31
13.37 ± 6.27
17.80 ± 6.48
Head kidney
26.59 ± 9.13
19.11 ± 5.15
7.24 ± 1.89
13.14 ± 4.92
24.12 ± 7.00
Liver
60.14 ± 24.25
25.32 ± 13.09
9.30 ± 3.11
71.70 ± 55.32
39.32 ± 22.19
Thymus
1.13 ± 0.31
1.33 ± 0.48
−1.38 ± 0.35
−1.14 ± 0.52
1.25 ± 0.28
il10
Spleen
1.24 ± 0.33
1.26 ± 0.27
1.46 ± 0.41
1.19 ± 0.35
1.29 ± 0.38
Head kidney
20.39 ± 9.00
54.04 ± 18.64
10.35 ± 4.94
11.83 ± 6.24
15.53 ± 6.49
Liver
2.52 ± 0.88
3.19 ± 1.12
3.08 ± 0.84
3.20 ± 0.95
3.63 ± 1.14
Thymus
1.51 ± 0.52
1.59 ± 0.50
1.41 ± 0.47
1.41 ± 0.38
1.15 ± 0.32
tgfb
Spleen
1.11 ± 0.08
−1.05 ± 0.09
1.14 ± 0.15
1.04 ± 0.11
−1.06 ± 0.12
Head kidney
1.17 ± 0.12
1.10 ± 0.09
1.14 ± 0.12
1.06 ± 0.14
−1.11 ± 0.13
Liver
1.34 ± 0.14
1.50 ± 0.18
2.17 ± 0.35
1.76 ± 0.24
1.50 ± 0.20
Thymus
−1.13 ± 0.16
−1.40 ± 0.22
−1.42 ± 0.33
−1.21 ± 0.24
−1.06 ± 0.16
Significant expression difference () between the infected and the control groups is indicated in bold.
