Research Article
Assessment of Physicochemical Properties of Rituximab Related to Its Immunomodulatory Activity
Table 3
Isoelectric point by cIEF. Variation is presented as confidence interval at 95% (
= 3).
| | Product | Batch | Main isoform (pI units) | Most acidic variant
(pI units) | Most basic variant
(pI units) | Global pI
(pI units) |
| | MabThera | M0605 | 9.31 ± 0.00 | 8.68 ± 0.00 | 9.49 ± 0.00 | 9.07 ± 0.06 | | N3518 | 9.31 ± 0.00 | 8.68 ± 0.00 | 9.49 ± 0.00 | 9.09 ± 0.06 | | B62222 | 9.31 ± 0.00 | 8.68 ± 0.00 | 9.49 ± 0.00 | 9.09 ± 0.06 |
| | Kikuzubam | 5445130608 | 9.30 ± 0.00 | 8.64 ± 0.00 | 9.42 ± 0.00 | 9.03 ± 0.07 | | 5445131015 | 9.30 ± 0.01 | 8.64 ± 0.01 | 9.42 ± 0.00 | 9.02 ± 0.08 | | 5445131216 | 9.29 ± 0.01 | 8.63 ± 0.01 | 9.42 ± 0.00 | 9.01 ± 0.08 |
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