Journal of Immunology Research / 2015 / Article / Tab 3

Research Article

Assessment of Physicochemical Properties of Rituximab Related to Its Immunomodulatory Activity

Table 3

Isoelectric point by cIEF. Variation is presented as confidence interval at 95% ( = 3).

ProductBatchMain isoform (pI units)Most acidic variant
(pI units)
Most basic variant
(pI units)
Global pI
(pI units)

MabTheraM06059.31 ± 0.008.68 ± 0.009.49 ± 0.009.07 ± 0.06
N35189.31 ± 0.008.68 ± 0.009.49 ± 0.009.09 ± 0.06
B622229.31 ± 0.008.68 ± 0.009.49 ± 0.009.09 ± 0.06

Kikuzubam54451306089.30 ± 0.008.64 ± 0.009.42 ± 0.009.03 ± 0.07
54451310159.30 ± 0.018.64 ± 0.019.42 ± 0.009.02 ± 0.08
54451312169.29 ± 0.018.63 ± 0.019.42 ± 0.009.01 ± 0.08

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